More than 130 suppliers
ISO certified
In-house tech support
we Connect you
Bio-Connect
ProductsBack/DAPT [208255-80-5]
Chemical Structure
Chemical Structure
Chemical Structure

DAPT [208255-80-5]

Research Use Only
AG-CR1-0016
AdipoGen Life Sciences
CAS Number208255-80-5
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight432.5
Price on request
Packing Size
Large volume orders?
Order with a bulk request
More than 130 suppliers
ISO certified
In-house tech support

Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    DAPT [208255-80-5]
  • Delivery Days Customer
    10
  • CAS Number
    208255-80-5
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Molecular Formula
    C23H26F2N2O4
  • Molecular Weight
    432.5
  • Scientific Description
    Cell permeable gamma-secretase inhibitor (IC50 = 115 nM for total beta-amyloid, IC50 = 200 nM for beta-amyloid 1-42) [1]. Reduces Abeta levels in vivo [2]. Blocks the proteolytic processing of neurotrophin receptor alike death domain protein (NRADD) [3]. Does not inhibit persenilinase [4]. Notch processing inhibitor [5]. Enhances neuronal differentiation independent of sonic hedgehog (Shh) signaling [6]. CDK5 activity inhibitor [7]. Apoptosis enhancer [8]. Inhibitor of slurp-like1 expression in the floor plate of the neural tube. - Chemical. CAS: 208255-80-5. Formula: C23H26F2N2O4. MW: 432.5. Cell permeable gamma-secretase inhibitor (IC50 = 115 nM for total beta-amyloid, IC50 = 200 nM for beta-amyloid 1-42). Reduces Abeta levels in vivo. Blocks the proteolytic processing of neurotrophin receptor alike death domain protein (NRADD). Does not inhibit persenilinase. Notch processing inhibitor. Enhances neuronal differentiation independent of sonic hedgehog (Shh) signaling. CDK5 activity inhibitor. Apoptosis enhancer.
  • SMILES
    C[C@H](NC(=O)CC1=CC(F)=CC(F)=C1)C(=O)N[C@H](C(=O)OC(C)(C)C)C1=CC=CC=C1
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain: H.F. Dovey, et al.; J. Neurochem. 76, 173 (2001)
  • The gamma-secretase inhibitor N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester reduces A beta levels in vivo in plasma and cerebrospinal fluid in young (plaque-free) and aged (plaque-bearing) Tg2576 mice: T.A. Lanz, et al.; J. Pharmacol. Exp. Ther. 305, 864 (2003)
  • Release of a membrane-bound death domain by gamma-secretase processing of the p75NTR homolog NRADD: K. Gowrishankar, et al.; J. Cell. Sci. 117, 4099 (2004)
  • Presenilin endoproteolysis mediated by an aspartyl protease activity pharmacologically distinct from gamma-secretase: W.A. Campbell, et al.; J. Neurochem. 85, 1563 (2003)
  • A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish: A. Geling, et al.; EMBO Rep. 3, 688 (2002)
  • The notch response inhibitor DAPT enhances neuronal differentiation in embryonic stem cell-derived embryoid bodies independently of sonic hedgehog signaling: T.Q. Crawford & H. Roelink; Dev. Dyn. 236, 886 (2007)
  • The Notch signaling inhibitor DAPT down-regulates cdk5 activity and modulates the distribution of neuronal cytoskeletal proteins: J. Kanungo, et al.; J. Neurochem. 106, 2236 (2008)
  • DAPT enhances the apoptosis of human tongue carcinoma cells: B.E. Grottklau, et al.; Int. J. Oral Sci. 1, 81 (2009)