Darunavir

AdipoGen Life Sciences

Darunavir [206361-99-1]

10

Research Use Only

>98%

C27H37N3O7S

547.7

Chemical. CAS: 206361-99-1. Formula: C27H37N3O7S. MW: 547.7. Darunavir is a highly potent HIV protease inhibitor (IC50=3-6nM, depending on laboratory HIV-1 strain), an antiretroviral medication used to treat and prevent HIV/AIDS. Darunavir is a second generation HIV-1 protease inhibitor that inhibits replication of various laboratory strains and clinical isolates of HIV-1, including those resistant to first generation protease inhibitors. It inhibits cell-free diffusion and cell-to-cell spread of HIV-1 in Jurkat cell populations. Formulations containing darunavir have been used in combination therapy for the treatment of HIV. Shown in a SARS-CoV-2 protease structure model study to potentially bind and inhibit the papain like viral protease (PLVP) of SARS-CoV-2. - Darunavir is a highly potent HIV protease inhibitor (IC50=3-6nM, depending on laboratory HIV-1 strain), an antiretroviral medication used to treat and prevent HIV/AIDS. Darunavir is a second generation HIV-1 protease inhibitor that inhibits replication of various laboratory strains and clinical isolates of HIV-1, including those resistant to first generation protease inhibitors. It inhibits cell-free diffusion and cell-to-cell spread of HIV-1 in Jurkat cell populations. Formulations containing darunavir have been used in combination therapy for the treatment of HIV. The Darunavir ethanolate (Prod. No. AG-CR1-3724) formulation has some stability advantages compared to the free base Darunavir. Shown in a SARS-CoV-2 protease structure model study to potentially bind and inhibit the papain-like viral protease (PLVP) of SARS-CoV-2, responsible for COVID-19.

NC1=CC=C(S(=O)(N(C[C@@H](O)[C@H](CC2=CC=CC=C2)NC(O[C@H]3CO[C@]4([H])[C@@]3([H])CCO4)=O)CC(C)C)=O)C=C1

-20°C,2°C to 8°C

12352200