
IHC-P analysis of mouse testis using GTX89448 DAZL antibody, Internal.
DAZL antibody, Internal
GTX89448
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetDAZL
Overview
- SupplierGeneTex
- Product NameDAZL antibody, Internal
- Delivery Days Customer7
- Application Supplier NoteWB: 0.5-1microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.50 mg/ml
- ConjugateUnconjugated
- Gene ID1618
- Target nameDAZL
- Target descriptiondeleted in azoospermia like
- Target synonymsDAZH, DAZL1, DAZLA, SPGYLA, deleted in azoospermia-like, DAZ homolog, DAZ-like autosomal, SPGY-like-autosomal, deleted in azoospermia-like 1, germline specific RNA binding protein, spermatogenesis gene on the Y-like autosomal, testis secretory sperm-binding protein Li 204a
- HostGoat
- IsotypeIgG
- Protein IDQ92904
- Protein NameDeleted in azoospermia-like
- Scientific DescriptionThe DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Le Rolle M, Massa F, Siggers P, et al. Arrest of WNT/β-catenin signaling enables the transition from pluripotent to differentiated germ cells in mouse ovaries. Proc Natl Acad Sci U S A. 2021,118(30). doi: 10.1073/pnas.2023376118Read this paper
- Chassot AA, Le Rolle M, Jolivet G, et al. Retinoic acid synthesis by ALDH1A proteins is dispensable for meiosis initiation in the mouse fetal ovary. Sci Adv. 2020,6(21):eaaz1261. doi: 10.1126/sciadv.aaz1261Read this paper






