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ProductsBack/DC-SIGN Antibody / CD209

DC-SIGN Antibody / CD209

Research Use Only
ORB639705
Biorbyt
ApplicationsImmunoHistoChemistry
Product group Antibodies
Price on request
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More than 130 suppliers
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Overview

  • Supplier
    Biorbyt
  • Product Name
    DC-SIGN Antibody / CD209
  • Delivery Days Customer
    16
  • Applications
    ImmunoHistoChemistry
  • Applications Supplier
    Immunohistochemistry (FFPE): 1-2ug/ml IHC-P
  • Certification
    Research Use Only
  • Clone ID
    rC209/1781
  • Isotype
    IgG
  • Scientific Description
    DC-SIGN is a transmembrane receptor that is expressed on the surface of dendritic cells and macrophages. It is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization, which allows the receptor to bind multivalent ligands with high avidity.
  • UNSPSC
    12352203