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DC-SIGN antibody [MR-1] (PE)

Research Use Only
GTX43152
GeneTex
ApplicationsFlow Cytometry
Product group Antibodies
ReactivityHuman
TargetCD209
Price on request
Packing Size
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Overview

  • Supplier
    GeneTex
  • Product Name
    DC-SIGN antibody [MR-1] (PE)
  • Delivery Days Customer
    9
  • Antibody Specificity
    This antibody recognizes human DC-specific ICAM-3 grabbing nonintegrin (DC-SIGN).
  • Applications
    Flow Cytometry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    MR-1
  • Conjugate
    RPE
  • Gene ID30835
  • Target name
    CD209
  • Target description
    CD209 molecule
  • Target synonyms
    CD209 antigen; CDSIGN; CLEC4L; C-type lectin domain family 4 member L; DC-SIGN; DC-SIGN1; dendritic cell-specific ICAM-3-grabbing non-integrin 1; dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin; dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin; hDC-SIGN; HIV gpl20-binding protein
  • Host
    Mouse
  • Isotype
    IgG1
  • Scientific Description
    This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009]
  • Reactivity
    Human
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203

References

  • Dendritic cells respond to nasopharygeal carcinoma cells through annexin A2-recognizing DC-SIGN. Chao PZ et al., 2015 Jan 1, Oncotarget
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