DC-SIGN Antibody
ORB248128
ApplicationsWestern Blot
Product group Antibodies
Overview
- SupplierBiorbyt
- Product NameDC-SIGN Antibody
- Delivery Days Customer16
- ApplicationsWestern Blot
- Applications SupplierWestern blot: 2-5ug/ml WB
- CertificationResearch Use Only
- IsotypeIgG
- Scientific DescriptionDC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) also known as CD209, is part of the Lectin family of proteins. DC-SIGN is part of the innate immune response via its modulation of Toll-like Receptors. It is present on the surface of macrophages and dendritic cells and binds mannose carbohydrates, a class of PAMPS found on bacteria, fungi and viruses. PAMP stimulated DC-SIGN activates the Raf kinases Raf-1 and B-Raf. Raf-1 phosphorylates Ser276 of NF-kB p65 which serves as a binding site for histone acetyltransferases CREB-binding protein (CBP) and p300. Acetylation of NF-kB p65 leads to enhanced and prolonged anti-inflammatory cytokine IL-10 production.
- UNSPSC12352203