IP analysis of HeLa lysates using control IgG and Dynactin 1 antibody. The precipitates were detected by the same Dynactin 1 antibody.
IP analysis of HeLa lysates using control IgG and Dynactin 1 antibody. The precipitates were detected by the same Dynactin 1 antibody.
DCTN1 antibody [3D5-C6-D5]
GTX49164
ApplicationsImmunoPrecipitation, Western Blot
Product group Antibodies
ReactivityHuman
TargetDCTN1
Overview
- SupplierGeneTex
- Product NameDCTN1 antibody [3D5-C6-D5]
- Delivery Days Customer9
- ApplicationsImmunoPrecipitation, Western Blot
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID3D5-C6-D5
- ConjugateUnconjugated
- FormulationLiquid
- Gene ID1639
- Target nameDCTN1
- Target descriptiondynactin subunit 1
- Target synonyms150 kDa dynein-associated polypeptide; DAP-150; DP-150; dynactin 1 (p150, glued homolog, Drosophila); dynactin subunit 1; P135
- HostMouse
- IsotypeIgG2b
- Protein IDQ14203
- Protein NameDynactin subunit 1
- Scientific DescriptionThis gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq, Oct 2008]
- ReactivityHuman
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203