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DDO-7263 [2254004-96-9]

DDO-7263 [2254004-96-9]

T60487
TargetMol Chemicals
Estimated Purity99.75%
DownloadMSDS
Product group Chemicals
Molecular Weight273.24
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    DDO-7263 [2254004-96-9]
  • Delivery Days Customer
    4
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    DDO-7263
  • Estimated Purity
    99.75%
  • Molecular Formula
    C14H9F2N3O
  • Molecular Weight
    273.24
  • Scientific Description
    DDO-7263 is a 1,2,4-Oxadiazole derivative that upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome and the subsequent degradation of ubiquitinated Nrf2. DDO-7263 is a potent Nrf2 activator that activates the Nrf2-ARE signaling pathway and exerts anti-inflammatory activity [1].
  • Shelf life instruction
    3 years
  • SMILES
    Cc1ccc(cn1)-c1noc(n1)-c1ccc(F)c(F)c1
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Target Fishing Reveals a Novel Mechanism of 1,2,4-Oxadiazole Derivatives Targeting Rpn6, a Subunit of 26S Proteasome. Dai Z et al., 2022 Mar 24, J Med Chem
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