DDR1 (Ab-796) Antibody

Cusabio

DDR1 (Ab-796) Antibody

20

Western Blot, ELISA

Research Use Only

Polyclonal

Unconjugated

DDR1

discoidin domain receptor tyrosine kinase 1

CAK; CD167; CD167 antigen-like family member A; cell adhesion kinase; DDR; EDDR1; epithelial discoidin domain-containing receptor 1; HGK2; mammary carcinoma kinase 10; MCK10; NEP; neuroepithelial tyrosine kinase; neurotrophic tyrosine kinase, receptor, type 4; NTRK4; protein-tyrosine kinase RTK-6; PTK3; PTK3A; PTK3A protein tyrosine kinase 3A; RTK6; TRKE; tyrosine kinase DDR; tyrosine-protein kinase CAK

Rabbit

IgG

Epithelial discoidin domain-containing receptor 1

Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing By similarity. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11. di Marco E., J. Biol. Chem. 268:24290-24295(1993). Johnson J.D., Proc. Natl. Acad. Sci. U.S.A. 90:5677-5681(1993).

Human, Mouse, Rat

-20°C or -80°C

12352203