Immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using DEAF1 Polyclonal Antibody at dilution 1:40
Immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using DEAF1 Polyclonal Antibody at dilution 1:40
DEAF1 Polyclonal Antibody
E-AB-16381
Product group Antibodies
Overview
- SupplierElabscience
- Product NameDEAF1 Polyclonal Antibody
- Delivery Days Customer12
- Applications SupplierELISA IHC
- CertificationResearch Use Only
- Concentration1.4mg/ml
- Scientific DescriptionSuppressin, also known as DEAF1 (deformed epidermal autoregulatory factor 1), SPN, NUDR (nuclear DEAF-1-related transcriptional regulator), or ZMYND5 (zinc finger MYND domain-containing protein 5), is a transcription factor required for embryonic development. Suppressin contains one SAND domain and one C-terminal MYND-type zinc finger. It interacts with LMO4 and CLIM-2, suggesting that it plays a role mediating cell fate and embryonic pattern formation. Suppressin is expressed in a variety of tissues and localizes to the nucleus. Several isoforms exist due to alternative splicing and, depending on the isoform, Suppressin is secreted in some cell types. Secreted Suppressin can function to inhibit cell proliferation, arresting cells in the G0 or G1 phase. Mutations in the gene encoding Suppressin may result in a growth advantage leading to the development and progression of neoplasia. This suggest that Supressin is a potential target for cancer therapy.
- UNSPSC12352203