Debromohymenialdisine [125118-55-0]

Name: Debromohymenialdisine [125118-55-0]
SKU: AG-CN2-0068_A27
Price: 141 EUR
Availability: BackOrder

AG-CN2-0068

CAS Number125118-55-0

Product group Chemicals

Estimated Purity>95%

Molecular Weight245.2

Overview

Supplier
AdipoGen Life Sciences
Product Name
Debromohymenialdisine [125118-55-0, 75593-17-8]
Delivery Days Customer
10
CAS Number
125118-55-0
Certification
Research Use Only
Estimated Purity
>95%
Molecular Formula
C11H11N5O2
Molecular Weight
245.2
Scientific Description
Chemical. CAS: 75593-17-8 and 125118-55-0. Formula: C11H11N5O2. MW: 245.2. Isolated from sponge Axinella carteri. Protein kinase C (PKC) inhibitor. Inhibits the ATP binding site. Cytotoxic and insecticidal. G2 DNA damage checkpoint inhibitor. Check point kinases 1 (Chk1) and 2 (Chk2) inhibitor. Does not inhibit ataxia-telangiectasia mutated (ATM) or ATM-Rad3-related proteins. MAP kinase kinase 1 (MEK-1) inhibitor. Interleukin-1 (IL-1) inhibitor. Anti-osteoarthritic. Potential anti-Alzheimer agent. - Protein kinase C (PKC) inhibitor. Inhibits the ATP binding site [1]. Cytotoxic and insecticidal [2]. G2 DNA damage checkpoint inhibitor. Check point kinases 1 (Chk1) and 2 (Chk2) inhibitor [3, 4, 6]. Does not inhibit ataxia-telangiectasia mutated (ATM) or ATM-Rad3-related proteins [3, 4]. MAP kinase kinase 1 (MEK-1) inhibitor [5]. Interleukin-1 (IL-1) inhibitor. Anti-osteoarthritic [7]. Potential anti-Alzheimer agent [7].
SMILES
NC1=NC(=O)\C(N1)=C1/CCNC(=O)C2=C1C=CN2
Storage Instruction
-20°C,2°C to 8°C
UNSPSC
12352200

Effects of a protein kinase C inhibitor (PKCI) on the development of adjuvant-induced arthritis (AA) in rats: M. DiMartino, et al.; Inflamm. Res. 44, S123 (1995)
Bioactive alkaloids from the tropical marine sponge Axinella carteri: A. Supriyono, et al.; Z. Naturforsch. C 50, 669 (1995)
Inhibition of the G2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine: D. Curman, et al.; J. Biol. Chem. 276, 17914 (2001)
G2 DNA damage checkpoint inhibition and antimitotic activity of 13-hydroxy-15-oxozoapatlin: N.T. Rundle, et al.; J. Biol. Chem. 276, 48231 (2001)
Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1): D. Tasdemir, et al.; J. Med. Chem. 45, 529 (2002)
G2 checkpoint abrogators as anticancer drugs: T. Kawabe; Mol. Cancer Ther. 3, 513 (2004)
Cellular localization of debromohymenialdisine and hymenialdisine in the marine sponge Axinella sp. using a newly developed cell purification protocol: Y.F. Song, et al.; Mar. Biotechnol. 13, 868 (2011)