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Dehydroaltenusin

HY-100513A
MedChem Express
CAS Number31186-13-7
Product group Chemicals
Molecular Weight288.25
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Dehydroaltenusin [31186-13-7]
  • Delivery Days Customer
    10
  • CAS Number
    31186-13-7
  • Certification
    Research Use Only
  • Molecular Formula
    C15H12O6
  • Molecular Weight
    288.25
  • Scientific Description
    Dehydroaltenusin is a small molecule selective inhibitor of eukaryotic DNA polymerase alpha , a type of antibiotic produced by a fungus with an IC 50 value of 0.68 microM. The inhibitory mode of action of dehydroaltenusin against mammalian pol alpha activity is competitive with respect to the DNA template primer ( K i =0.23 microM) and non-competitive with respect to the 2-deoxyribonucleoside 5-triphosphate substrate ( K i =0.18 microM) [1] . Dehydroaltenusin arrests the cancer cell cycle at the S-phase and triggers apoptosis [1] . Dehydroaltenusin possesses anti-tumor activity against human adenocarcinoma tumor in vivo [1] .
  • SMILES
    O=C(C(O)=C1)C=C(C2=CC(OC)=CC(O)=C23)[C@@]1(C)OC3=O
  • UNSPSC
    12352200