Delgocitinib [1263774-59-9]
T15096
CAS Number1263774-59-9
Product group Chemicals
Estimated Purity99.90%
Molecular Weight310.35
Overview
- SupplierTargetMol Chemicals
- Product NameDelgocitinib [1263774-59-9]
- Delivery Days Customer9
- CAS Number1263774-59-9
- Category SupplierChemical
- CertificationResearch Use Only
- Chemical NameDelgocitinib
- Estimated Purity99.90%
- Molecular FormulaC16H18N6O
- Molecular Weight310.35
- Scientific DescriptionDelgocitinib (JTE-052) is a specific JAK (Janus kinase) inhibitor with IC50 values of 2.8, 2.6, 13, and 58 nM for JAK1, JAK2, JAK3, and Tyk2 respectively. Delgocitinib is involved in various inflammatory and autoimmune diseases through JAK-dependent cytokines and can effectively suppress multiple cytokine signaling while inhibiting itching caused by cytokines. It is widely used to treat various inflammatory diseases, including autoimmune diseases and hypersensitivity reactions.
- Shelf life instruction3 years
- SMILESC[C@H]1CN(C(=O)CC#N)[C@]11CCN(C1)c1ncnc2[nH]ccc12
- Storage Instruction-20°C
- UNSPSC12352200
References
- Pharmacological properties of JTE-052: a novel potent JAK inhibitor that suppresses various inflammatory responses in vitro and in vivo. Tanimoto A et al., 2015 Jan, Inflamm ResRead more
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