delta12-Prostaglandin D2 [64072-89-5]

TargetMol Chemicals

delta12-Prostaglandin D2 [64072-89-5]

16

64072-89-5

Chemical

Research Use Only

Δ12-Prostaglandin D2

C20H32O5

352.5

Prostaglandin D2 (PGD2) is a primary enzymatic prostaglandin derived from PGH2 and is abundantly produced in the cerebrospinal fluid (CSF) by the lipocalin-type PGD synthase, and peripherally by myeloid cells such as mast cells and basophils via a hematopoietic-type PGD synthase. PGD2 is chemically unstable and presents challenges for use and analysis due to its brief in vivo half-life. delta12-PGD2, an initial decomposition product of PGD2, acts as an intermediate in the pathway to delta12-PGJ2, a cyclopentenone prostaglandin known for its antimitotic and carcinogenic properties. The metabolism of delta12-PGD2 involves the addition of thiol nucleophiles, a common pathway for many cyclopentenone prostaglandins.

3 years

C(/C=C\CCCC(O)=O)[C@@H]1/C(=C\C[C@H](CCCCC)O)/C(=O)C[C@@H]1O

-20°C

12352200