Demethoxycurcumin [22608-11-3]

Chemodex

Demethoxycurcumin [22608-11-3]

10

9

22608-11-3

Research Use Only

>98%

Warning

C20H18O5

338.35

Chemical. CAS: 22608-11-3. Formula: C20H18O5. MW: 338.35. Demethoxycurcumin (DMC) is a natural demethoxy derivative of curcumin with anti-inflammatory and anti-cancer properties. DMC suppresses cell proliferation, migration and invasion in cancer cells. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/beta-catenin pathway, and inhibits lipopolysaccharide induction of iNOS by blocking NF-kappa activation. It also has been shown to inhibit energy metabolic and oncogenic signaling pathways through AMPK activation. In addition it is a potent inhibitor of P-Type ATPases. Shown to have neuroprotective properties. It also has anti-plasmodial activity. - Demethoxycurcumin (DMC) is a natural demethoxy derivative of curcumin with anti-inflammatory and anti-cancer properties. DMC suppresses cell proliferation, migration and invasion in cancer cells. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/beta-catenin pathway, and inhibits lipopolysaccharide induction of iNOS by blocking NF-kappa activation. It also has been shown to inhibit energy metabolic and oncogenic signaling pathways through AMPK activation. In addition it is a potent inhibitor of P-Type ATPases. Shown to have neuroprotective properties. It also has anti-plasmodial activity.

OC1=CC=C(/C=C/C(CC(/C=C/C2=CC=C(O)C(OC)=C2)=O)=O)C=C1

2°C to 8°C,RT

3077

12352200