Demethoxyfumitremorgin C [111768-16-2]

TargetMol Chemicals

Demethoxyfumitremorgin C [111768-16-2]

9

Research Use Only

C21H23N3O2

349.434

Demethoxyfumitremorgin C and tryprostatin B are fungal inhibitors of mammalian cell cycle progression at the G(2)/M transition. Demethoxyfumitremorgin C inhibits the proliferation of PC3 human prostate cancer cells via the intrinsic (mitochondrial) and extrinsic pathway, followed by downstream events leading to apoptotic cell death, it could therefore, serve as a useful agent to treat human advanced prostate cancer.

[H][C@@]12CCCN1C(=O)[C@]1([H])Cc3c([nH]c4ccccc34)[C@H](C=C(C)C)N1C2=O - wU:1.0,8.9,wD:20.23,(-6.13,-6.74,;-5.74,-5.25,;-7.26,-5.51,;-7.97,-4.14,;-6.89,-3.04,;-5.51,-3.73,;-4.08,-3.17,;-3.85,-1.64,;-2.87,-4.13,;-2.64,-2.6,;-1.44,-3.56,;-.23,-4.52,;-.46,-6.04,;.91,-6.73,;1.99,-5.63,;3.53,-5.7,;4.36,-4.4,;3.65,-3.04,;2.11,-2.97,;1.28,-4.27,;-1.9,-6.61,;-2.12,-8.13,;-.92,-9.09,;-1.15,-10.61,;.51,-8.53,;-3.1,-5.65,;-4.53,-6.21,;-4.76,-7.74,) -

-20°C

12352200