Chemical Structure
Chemical Structure
DETA NONOate [146724-94-9]
AG-CR1-3614
Overview
- SupplierAdipoGen Life Sciences
- Product NameDETA NONOate [146724-94-9]
- Delivery Days Customer10
- CAS Number146724-94-9
- CertificationResearch Use Only
- Estimated Purity>98%
- Hazard InformationWarning
- Molecular FormulaC4H13N5O2
- Molecular Weight163.2
- Scientific DescriptionChemical. CAS: 146724-94-9. Formula: C4H13N5O2. MW: 163.2. Nitric oxide (NO) donor. The slow release of NO allows the use in experiments investigating the effects of prolonged constant NO delivery to cells and tissues. The half-life time is 20 hours at 37°C and 56 hours at 22-25°C in 0.1M phosphate buffer, pH 7.4. Liberates 2 mol of NO per mol of parent compound. Decomposition of NONOates is nearly instantaneous at pH 5.0. - Nitric oxide (NO) donor. The slow release of NO allows the use in experiments investigating the effects of prolonged constant NO delivery to cells and tissues. The half-life time is 20 hours at 37°C and 56 hours at 22-25°C in 0.1M phosphate buffer, pH 7.4. Liberates 2 mol of NO per mol of parent compound. Decomposition of NONOates is nearly instantaneous at pH 5.0.
- SMILESNCCN(CC[NH3+])N([O-])N=O
- Storage Instruction-20°C,-80°C
- UNSPSC12352200
References
- New nitric oxide-releasing zwitterions derived from polyamines: J.A. Hrabie, et al.; J. Org. Chem. 58, 1472 (1993)
- Nitric oxide/nucleophile complexes: a unique class of nitric oxide-based vasodilators: L.K. Keefer & D. Morley; J. Cardiovasc. Pharmacol. 22, 3 (1993)
- Intracerebroventricular administration of a nitric oxide-releasing compound, NOC-18, produces thermal hyperalgesia in rats: S. Shibuta, et al.; Neurosci. Lett. 187, 103 (1995)
- NOC, a nitric-oxide-releasing compound, induces dose dependent apoptosis in macrophages: M. Shimaoka, et al.; BBRC 209, 519 (1995)
- Nitric oxide (NO) donor molecules: effect of NO release rate on vascular smooth muscle cell proliferation in vitro: D.L. Mooradian, et al.; J. Cardiovasc. Pharmacol. 25, 674 (1995)
- NONOates (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: convenient nitric oxide dosage forms: L.K. Keefer, et al.; Methods Enzymol. 268, 281 (1996)
- The nitric oxide donor DETA-NONOate decreases matrix metalloproteinase-9 expression and activity in rat aortic smooth muscle and abdominal aortic explants: I. Sinha, et al.; Ann. Vasc. Surg. 20, 92 (2006)
- In vitro and in vivo sensitization of SW620 metastatic colon cancer cells to CDDP-induced apoptosis by the nitric oxide donor DETANONOate: Involvement of AIF: S. Huerta, et al.; Nitric Oxide 20, 182 (2009)
- Neuroprotective effects of nitric oxide donor NOC-18 against brain ischemia-induced mitochondrial damages: role of PKG and PKC: O. Arandarcikaite, et al.; Neurosci. Lett. 586, 65 (2015)