DHCR7 antibody

GeneTex

DHCR7 antibody

9

WB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1.46 mg/ml

Unconjugated

DHCR7

7-dehydrocholesterol reductase

SLOS, 7-dehydrocholesterol reductase, 7-DHC reductase, cholesterol-5,6-epoxide hydrolase subunit DHCR7, delta-7-dehydrocholesterol reductase, delta7-sterol reductase, putative sterol reductase SR-2, sterol delta-7-reductase, sterol reductase SR-2

Rabbit

IgG

7-dehydrocholesterol reductase

The DHCR7 gene encodes delta-7-sterol reductase (EC 1.3.1.21), the penultimate enzyme of mammalian sterol biosynthesis that converts 7-dehydrocholesterol (7-DHC) to cholesterol. This enzyme removes the C(7-8) double bond introduced by the sterol delta8-delta7 isomerases. In addition, its role in drug-induced malformations is known: inhibitors of the last step of cholesterol biosynthesis such as AY9944 and BM15766 severely impair brain development (Moebius et al., 1998 [PubMed 9465114]).[supplied by OMIM]

Human, Mouse, Rat

-20°C or -80°C,2°C to 8°C

41116161