DHCR7 antibody
GTX130695
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetDHCR7
Overview
- SupplierGeneTex
- Product NameDHCR7 antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1.46 mg/ml
- ConjugateUnconjugated
- Gene ID1717
- Target nameDHCR7
- Target description7-dehydrocholesterol reductase
- Target synonyms7-dehydrocholesterol reductase; 7-DHC reductase; delta-7-dehydrocholesterol reductase; delta7-sterol reductase; putative sterol reductase SR-2; SLOS; sterol delta-7-reductase; sterol reductase SR-2
- HostRabbit
- IsotypeIgG
- Protein IDQ9UBM7
- Protein Name7-dehydrocholesterol reductase
- Scientific DescriptionThe DHCR7 gene encodes delta-7-sterol reductase (EC 1.3.1.21), the penultimate enzyme of mammalian sterol biosynthesis that converts 7-dehydrocholesterol (7-DHC) to cholesterol. This enzyme removes the C(7-8) double bond introduced by the sterol delta8-delta7 isomerases. In addition, its role in drug-induced malformations is known: inhibitors of the last step of cholesterol biosynthesis such as AY9944 and BM15766 severely impair brain development (Moebius et al., 1998 [PubMed 9465114]).[supplied by OMIM]
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- INPP5K and SIL1 associated pathologies with overlapping clinical phenotypes converge through dysregulation of PHGDH. Hathazi D et al., 2021 Sep 4, BrainRead more
- New Inhibitory Effect of Latilactobacillus sakei UONUMA on the Cholesterol Biosynthesis Pathway in Human HepG2 Cells. Ohta-Shimizu M et al., 2021, Biol Pharm BullRead more