DHFR-IN-1

TargetMol Chemicals

DHFR-IN-1

65

2757991-65-2

Chemical

DHFR-IN-1

C22H22N6O4S2

498.58

DHFR-IN-1 is a selective and potent inhibitor of DHFR (dihydrofolate reductase) (IC50: 40.71 nM). DHFR-IN-1 exhibited some antifungal activity and good antibacterial activity against Gram-positive and Gram-negative bacteria.DHFR-IN-1 showed good synergy with Levofloxacin with FIC (partial inhibitory concentration index) = 0.249.

3 years

N(NC1=NC(=CS1)C2=CC=C(O)C=C2)=C3C=4C(NC3=O)=CC=C(S(=O)(=O)N5CCN(C)CC5)C4

-20°

12352200