DHFR-IN-8

MedChem Express

DHFR-IN-8

14

Research Use Only

C18H14N6S

346.41

DHFR-IN-8 (compound 6r) is a dihydrofolate reductase (DHFR) inhibitor that affects purine and thymidylate biosynthesis in cell proliferation and growth. DHFR-IN-8 inhibits methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300 (IC50=15.6 ng/mL) in mouse models of systemic infection and thigh infection[1].

NC1=NC2=C(C(N)=N1)C(C=CN3CC4=CC=C5SC=NC5=C4)=C3C=C2

12352200