DHFR-IN-9

MedChem Express

DHFR-IN-9

14

Research Use Only

C19H16N6S

360.44

DHFR-IN-9 (compound 8A) is a dihydrofolate reductase (DHFR) inhibitor that affects purine and thymidylate biosynthesis in cell proliferation and growth. DHFR-IN-9 inhibits methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300 (IC50=0.25 microg/mL) and has anti-infective effects in mouse models of systemic infection and thigh infection caused by it (dose: 2.5 mg /kg, 5 mg/kg; ip). DHFR-IN-9 has stronger anticancer activity than paclitaxel (Y-B0015) in a mouse model of breast cancer (dose: 2.5 mg/kg; ip; once every 3 days)[1].

NC1=NC2=C(C(N)=N1)C(C=C(C)N3CC4=NC5=CC=CC=C5S4)=C3C=C2

12352200