DHX36 Antibody, FITC conjugated

Cusabio

DHX36 Antibody, FITC conjugated

20

Research Use Only

Polyclonal

FITC

DHX36

DEAH-box helicase 36

ATP-dependent DNA/RNA helicase DHX36; ATP-dependent RNA helicase DHX36; DDX36; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 36; DEAD/H box polypeptide 36; DEAH (Asp-Glu-Ala-His) box polypeptide 36; DEAH box protein 36; G4 resolvase-1; G4R1; MLEL1; MLE-like protein 1; probable ATP-dependent RNA helicase DHX36; RHAU; RNA helicase associated with AU-rich element ARE; RNA helicase associated with AU-rich element protein

Rabbit

IgG

ATP-dependent RNA helicase DHX36

Proposed to have a global role in regulating mRNA expression including transcriptional regulation and mRNA stability. Binds with high affinity to and resolves tetramolecular RNA and DNA quadruplex structures. Unwinds intramolecular quadruplexes derived from the ZIC1 and the MYC promoters. Binds to quadruplex structures in the promoters of YY1 and ALPL genes and regulates their expression. Binds to telomerase RNA template component (TERC) 5\-end (nucleotides 1-43) and unwinds an internal quadruplex formation in TERC 5\-end to promote P1 helix formation; the P1 helix acts as a template boundary ensuring accurate reverse transcription and is disrupted by quadruplex formation. May be involved in regulation of telomere length. Plays a role in degradation and deadenylation of mRNAs containing in their 3\-UTR the consensus ARE sequence element. May function in sex development and spermatogenesis. May play a role in ossification.

Human

-20°C or -80°C

12352203