DI-1859 [2247061-09-0]

TargetMol Chemicals

DI-1859 [2247061-09-0]

10

Chemical

Research Use Only

DI-1859

C30H45N5O3S

555.78

DI-1859 is a selective, potent and covalent inhibitor of DCN1. At low nanomolar concentrations, DI-1859 inhibits the neddylation of cullin 3 in cells. DI-1859 induces a significant increase in NRF2 protein, a CRL3 substrate, in mouse liver and effectively protects mice from acetaminophen-induced liver injury.

3 years

CCC(=O)N[C@@H](Cc1nc2ccc(cc2s1)C(C)C)C(=O)N[C@H](CNC(=O)C(=C)CN(C)C)C1CCCCC1

-20°C

12352200