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Dibenzoylmethane, 98% [120-46-7]

Research Use Only
D3304
LKT Laboratories
Estimated Purity≥98%
Product group Chemicals
€ 107,00
25 g
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Overview

  • Supplier
    LKT Laboratories
  • Product Name
    Dibenzoylmethane, 98% [120-46-7]
  • Delivery Days Customer
    7
  • Certification
    Research Use Only
  • Estimated Purity
    ≥98%
  • Format
    Insoluble in water. Soluble in ether, chloroform, and aqueous NaOH.
  • Scientific Description
    Aromatic 1,3-diketone acetylacetone derivative found in Glycyrrhiza (licorice); cytoprotective.; Phenyl Phenacyl Ketone, gamma-Hydroxychalkone
  • Storage Instruction
    Ambient
  • UNSPSC
    12352200

References

  • Hegedűs C, Lakatos P, Kiss-Szikszai A, et al. Cytoprotective dibenzoylmethane derivatives protect cells from oxidative stress-induced necrotic cell death. Pharmacol Res. 2013 Jun;72:25-34. PMID: 23523665. Anand P, Sung B, Kunnumakkara AB, et al. Suppression of pro-inflammatory and proliferative pathways by diferuloylmethane (curcumin) and its analogues dibenzoylmethane, dibenzoylpropane, and dibenzylideneacetone: role of Michael acceptors and Michael donors. Biochem Pharmacol. 2011 Dec 15;82(12):1901-9. PMID: 21924245. Lin W, Hong JL, Shen G, et al. Pharmacokinetics of dietary cancer chemopreventive compound dibenzoylmethane in rats and the impact of nanoemulsion and genetic knockout of Nrf2 on its disposition. Biopharm Drug Dispos. 2011 Mar;32(2):65-75. PMID: 21341276. Dietary feeding of dibenzoylmethane inhibits prostate cancer in transgenic adenocarcinoma of the mouse prostate model. Khor TO, Yu S, Barve A, et al. Cancer Res. 2009 Sep 1;69(17):7096-102. PMID: 19706764. Thimmulappa RK, Rangasamy T, Alam J, et al. Dibenzoylmethane activates Nrf2-dependent detoxification pathway and inhibits benzo(a)pyrene induced DNA adducts in lungs. Med Chem. 2008 Sep;4(5):473-81. PMID: 18782044. Shen G, Khor TO, Hu R, et al. Chemoprevention of familial adenomatous polyposis by natural dietary compounds sulforaphane and dibenzoylmethane alone and in combination in ApcMin/+ mouse. Cancer Res. 2007 Oct 15;67(20):9937-44. PMID: 17942926.