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ProductsBack/Difluoromethylornithine Hydrochloride Monohydrate [96020-91-6]

Difluoromethylornithine Hydrochloride Monohydrate [96020-91-6]

Research Use Only
D3221
LKT Laboratories
Estimated Purity≥98%
Product group Chemicals
€ 192,00
25 mg
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More than 130 suppliers
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Overview

  • Supplier
    LKT Laboratories
  • Product Name
    Difluoromethylornithine Hydrochloride Monohydrate [96020-91-6]
  • Delivery Days Customer
    7
  • Certification
    Research Use Only
  • Estimated Purity
    ≥98%
  • Format
    Soluble in water. Insoluble in acetone or chloroform.
  • Scientific Description
    Ornithine decarboxylase inhibitor.; Eflornithine HCl H2O, DFMO HCl H2O
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Singh AK, Roberts S, Ullman B, et al. A quantitative proteomic screen to identify potential drug resistance mechanism in alfa-difluoromethylornithine (DFMO) resistant Leishmania donovani. J Proteomics. 2014 May 6;102:44-59. PMID: 24631822. Tysoe C, Withers SG. Fluorinated mechanism-based inhibitors: common themes and recent developments. Curr Top Med Chem. 2014;14(7):865-74. PMID: 24484426. Arumugam A, Weng Z, Talwelkar SS, et al. Inhibiting cycloxygenase and ornithine decarboxylase by diclofenac and alpha-difluoromethylornithine blocks cutaneous SCCs by targeting Akt-ERK axis. PLoS One. 2013 Nov 8;8(11):e80076. PMID: 24260338. Xu H, Washington S, Verderame MF, et al. Activation of protein kinase A (PKA) signaling mitigates the antiproliferative and antiinvasive effects of alpha-difluoromethylornithine in breast cancer cells. Breast Cancer Res Treat. 2008 Jan;107(1):63-70. PMID: 17333334. Lima e Silva R, Saishin Y, Saishin Y, et al. Suppression and regression of choroidal neovascularization by polyamine analogues. Invest Ophthalmol Vis Sci. 2005 Sep;46(9):3323-30. PMID: 16123436. Fong LY, Nguyen VT, Pegg AE, et al. Alpha-difluoromethylornithine induction of apoptosis: a mechanism which reverses pre-established cell proliferation and cancer initiation in esophageal carcinogenesis in zinc-deficient rats. Cancer Epidemiol Biomarkers Prev. 2001 Mar;10(3):191-9. PMID: 11303587.