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ProductsBack/Dihydromethysticin [19902-91-1]

Dihydromethysticin [19902-91-1]

Research Use Only
D3227
LKT Laboratories
Estimated Purity≥97%
Product group Chemicals
€ 329,00
5 mg
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Overview

  • Supplier
    LKT Laboratories
  • Product Name
    Dihydromethysticin [19902-91-1]
  • Delivery Days Customer
    7
  • Certification
    Research Use Only
  • Estimated Purity
    ≥97%
  • Scientific Description
    Kavalactone originally found in Piper methysticum (kava plant); Voltage-gated Na+ and L-type Ca2+ channel blocker.; 2H-Pyran-2-one,6-(2-(1,3-benzodioxol-5-yl)ethyl)-5,6-dihydro-4-methoxy-, (S)-, 7,8-Dihydromethysticin
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Narayanapillai SC, Balbo S, Leitzman P, et al. Dihydromethysticin (DHM) from kava blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis and differentially reduces DNA damage in A/J mice. Carcinogenesis. 2014 Jul 22. [Epub ahead of print]. PMID: 25053626. Xuan TD, Elzaawely AA, Fukuta M, et al. Herbicidal and Fungicidal Activities of Lactones in Kava (Piper methysticum). J Agric Food Chem. 2006 Feb 8;54(3):720-5. PMID: 16448174. Friese J, Gleitz J. Kavain, dihydrokavain, and dihydromethysticin non-competitively inhibit the specific binding of [3H]-batrachotoxinin-A 20-alpha-benzoate to receptor site 2 of voltage-gated Na+ channels. Planta Med. 1998 Jun;64(5):458-9. PMID: 9690349. Backhauss C, Krieglstein J. Extract of kava (Piper methysticum) and its methysticin constituents protect brain tissue against ischemic damage in rodents. Eur J Pharmacol. 1992 May 14;215(2-3):265-9. PMID: 1396990.