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Chemical Structure
Chemical Structure
Chemical Structure

Dihydrorhodamine 123 [109244-58-8]

Research Use Only
CDX-D0134
Chemodex
CAS Number109244-58-8
Product group Chemicals
Estimated Purity>95%
Molecular Weight346.38
Price on request
Packing Size
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Overview

  • Supplier
    Chemodex
  • Product Name
    Dihydrorhodamine 123 [109244-58-8]
  • Delivery Days Customer
    10
  • CAS Number
    109244-58-8
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Molecular Formula
    C21H18N2O3
  • Molecular Weight
    346.38
  • Scientific Description
    Cell-permeable non-fluorescent reactive oxygen species (ROS) indicator. Passively diffuses across membranes where it is oxidized by peroxynitrite to rhodamine 123 which localizes in the mitochondria and exhibits green fluorescence (Ex/Em wavelengths of 500 and 536 nm). Used to investigate reactive oxygen intermediates produced by human and murine phagocytes, activated rat mast cells and cultured endothelial cells. In addition, it has been used together with Fura Red calcium indicator to simultaneously measure oxidative bursts and Ca2+ fluxes in monocytes and granulocytes. Dihydrorhodamine 123 has been shown to be a more sensitive probe than H2DCFDA for detecting granulocyte respiratory bursts. - Chemical. CAS: 109244-58-8. Formula: C21H18N2O3. MW: 346.38. Synthetic. Cell-permeable non-fluorescent reactive oxygen species (ROS) indicator. Passively diffuses across membranes where it is oxidized by peroxynitrite to rhodamine 123 which localizes in the mitochondria and exhibits green fluorescence (Ex/Em wavelengths of 500 and 536 nm). Used to investigate reactive oxygen intermediates produced by human and murine phagocytes, activated rat mast cells and cultured endothelial cells. In addition, it has been used together with Fura Red calcium indicator to simultaneously measure oxidative bursts and Ca2+ fluxes in monocytes and granulocytes. Dihydrorhodamine 123 has been shown to be a more sensitive probe than H2DCFDA for detecting granulocyte respiratory bursts.
  • SMILES
    COC(=O)C1=CC=CC=C1C1C2=CC=C(N)C=C2OC2=C1C=CC(N)=C2
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200