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Dihydrotanshinone [87205-99-0]

Research Use Only
D3330
LKT Laboratories
Estimated Purity≥90%
Product group Chemicals
€ 251,00
10 mg
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Overview

  • Supplier
    LKT Laboratories
  • Product Name
    Dihydrotanshinone [87205-99-0]
  • Delivery Days Customer
    7
  • Certification
    Research Use Only
  • Estimated Purity
    ≥90%
  • Format
    Soluble in chloroform and acetone
  • Scientific Description
    Found in Salvia; fatty acid synthase and AChE inhibitor, mineralocorticoid and glucocorticoid antagonist.
  • Storage Instruction
    4°C
  • UNSPSC
    12352200

References

  • Cheung J, Beri V, Shiomi K, et al. Acetylcholinesterase Complexes with the Natural Product Inhibitors Dihydrotanshinone I and Territrem B: Binding Site Assignment from Inhibitor Competition and Validation Through Crystal Structure Determination. J Mol Neurosci. 2014 Feb 27. [Epub ahead of print]. PMID: 24573600. Suk FM, Jou WJ, Lin RJ, et al. 15,16-Dihydrotanshinone I-induced apoptosis in human colorectal cancer cells: involvement of ATF3. Anticancer Res. 2013 Aug;33(8):3225-31. PMID: 23898083. Jang TS, Zhang H, Kim G, et al. Bioassay-guided isolation of fatty acid synthase inhibitory diterpenoids from the roots of Salvia miltiorrhiza Bunge. Arch Pharm Res. 2012 Mar;35(3):481-6. PMID: 22477195. Trinh HT, Chae SJ, Joh EH, et al. Tanshinones isolated from the rhizome of Salvia miltiorrhiza inhibit passive cutaneous anaphylaxis reaction in mice. J Ethnopharmacol. 2010 Oct 28;132(1):344-8. PMID: 20732401. Liu Q, Zhang Y, Lin Z, et al. Danshen extract 15,16-dihydrotanshinone I functions as a potential modulator against metabolic syndrome through multi-target pathways. J Steroid Biochem Mol Biol. 2010 Jun;120(4-5):155-63. PMID: 20380878. Lam FF, Yeung JH, Chan KM, et al. Dihydrotanshinone, a lipophilic component of Salvia miltiorrhiza (danshen), relaxes rat coronary artery by inhibition of calcium channels. J Ethnopharmacol. 2008 Sep 26;119(2):318-21. PMID: 18682284. Park JW, Lee SH, Yang MK, et al. 15,16-dihydrotanshinone I, a major component from Salvia miltiorrhiza Bunge (Dansham), inhibits rabbit platelet aggregation by suppressing intracellular calcium mobilization. Arch Pharm Res. 2008 Jan;31(1):47-53. PMID: 18277607. Bian W, Chen F, Bai L, et al. Dihydrotanshinone I inhibits angiogenesis both in vitro and in vivo. Acta Biochim Biophys Sin (Shanghai). 2008 Jan;40(1):1-6. PMID: 18180848.