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ProductsBack/Dimebon Dihydrochloride [97657-92-6]

Dimebon Dihydrochloride [97657-92-6]

Research Use Only
D3349
LKT Laboratories
Estimated Purity≥98%
Product group Chemicals
€ 206,00
5 mg
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Overview

  • Supplier
    LKT Laboratories
  • Product Name
    Dimebon Dihydrochloride [97657-92-6]
  • Delivery Days Customer
    7
  • Certification
    Research Use Only
  • Estimated Purity
    ≥98%
  • Format
    H2O: ≥10 mg/mL
  • Scientific Description
    AMPK activator, L-type Ca2+ channel and NMDA, histamine H1/2, alfa-adrenergic, 5-HT2C/5A/6 receptor antagonist.; Dimebon 2HCl, Latrepirdine, Dimebolin Hydrochloride
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Coughlan KS, Mitchem MR, Hogg MC, et al. "Preconditioning" with latrepirdine, an adenosine 5'-monophosphate-activated protein kinase activator, delays amyotrophic lateral sclerosis progression in SOD1(G93A) mice. Neurobiol Aging. 2015 Feb;36(2):1140-50. PMID: 25443289. Shevtsova EF, Vinogradova DV, Kireeva EG, et al. Dimebon attenuates the Abèta-induced mitochondrial permeabilization. Curr Alzheimer Res. 2014;11(5):422-9. PMID: 24801220. Weisová P, Alvarez SP, Kilbride SM, et al. Latrepirdine is a potent activator of AMP-activated protein kinase and reduces neuronal excitability. Transl Psychiatry. 2013 Oct 22;3:e317. PMID: 24150226. Steele JW, Gandy S. Latrepirdine (Dimebon), a potential Alzheimer therapeutic, regulates autophagy and neuropathology in an Alzheimer mouse model. Autophagy. 2013 Apr;9(4):617-8. PMID: 23380933. Wu J, Li Q, Bezprozvanny I. Evaluation of Dimebon in cellular model of Huntington's disease. Mol Neurodegener. 2008 Oct 21;3:15. PMID: 18939977. Grigorev VV, Dranyi OA, Bachurin SO. Comparative study of action mechanisms of dimebon and memantine on AMPA- and NMDA-subtypes glutamate receptors in rat cerebral neurons. Bull Exp Biol Med. 2003 Nov;136(5):474-7. PMID: 14968164.