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ProductsBack/Dimethyl Fumarate [624-49-7]

Dimethyl Fumarate [624-49-7]

Research Use Only
D3448
LKT Laboratories
Estimated Purity≥98%
Product group Chemicals
€ 211,00
250 g
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Overview

  • Supplier
    LKT Laboratories
  • Product Name
    Dimethyl Fumarate [624-49-7]
  • Delivery Days Customer
    7
  • Certification
    Research Use Only
  • Estimated Purity
    ≥98%
  • Format
    Soluble in water (1.6 mg/ml at 20° C), methanol (30-36 mg/ml), ethanol (10 mg/ml at 25° C), DMSO (29 mg/ml at 25° C), and DMF (~12 mg/ml)
  • Scientific Description
    Fumaric acid methyl ester; nAChR agonist, indirect Nrf2 activator.; BG-12
  • Storage Instruction
    Ambient
  • UNSPSC
    12352200

References

  • Fox RJ, Miller DH, Phillips JT, et al. Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis. N Engl J Med. 2012 Sep 20;367(12):1087-97. Erratum in: N Engl J Med. 2012 Oct 25;367(17):1673. PMID: 22992072. Scannevin RH, Chollate S, Jung MY, et al. Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway. J Pharmacol Exp Ther. 2012 Apr;341(1):274-84. PMID: 22267202. Lehmann JC, Listopad JJ, Rentzsch CU, et al. Dimethylfumarate induces immunosuppression via glutathione depletion and subsequent induction of heme oxygenase 1. J Invest Dermatol. 2007 Apr;127(4):835-45. PMID: 17235328. Held KD, Epp ER, Clark EP, et al. Effect of dimethyl fumarate on the radiation sensitivity of mammalian cells in vitro. Radiat Res. 1988 Sep;115(3):495-502. PMID: 3174933.