DKK1 Protein, Human, Recombinant (Avi & His), Biotinylated

TargetMol Chemicals

DKK1 Protein, Human, Recombinant (Avi & His), Biotinylated

16

Research Use Only

35-50 KDa (reducing condition)

Dickkopf-related protein 1(DKK-1), is a member of the dickkopf family. DKK1 secreted proteins with two cysteine-rich domains separated by a linker region. It antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.

-20°C

12352200