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DLK/MAP3K12 antibody

Research Use Only
GTX124127
GeneTex
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetMap3k12
Price on request
Packing Size
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More than 130 suppliers
ISO certified
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Overview

  • Supplier
    GeneTex
  • Product Name
    DLK/MAP3K12 antibody
  • Delivery Days Customer
    9
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID26404
  • Target name
    Map3k12
  • Target description
    mitogen-activated protein kinase kinase kinase 12
  • Target synonyms
    DL; DLK; dual leucine zipper bearing kinase; leucine-zipper protein kinase; MAPK-upstream kinase; mitogen-activated protein kinase kinase kinase 12; mixed lineage kinase; MUK; zipper (leucine) protein kinase; Zp; Zpk
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro.
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    2°C to 8°C,-20°C or -80°C
  • UNSPSC
    12352203

References

  • Optic nerve regeneration screen identifies multiple genes restricting adult neural repair. Lindborg JA et al., 2021 Mar 2, Cell Rep
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  • MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer. Augert A et al., 2020 Jul 13, Cancer Cell
    Read more
  • The Map3k12 (Dlk)/JNK3 signaling pathway is required for pancreatic beta-cell proliferation during postnatal development. Tenenbaum M et al., 2021 Jan, Cell Mol Life Sci
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  • Targeted disruption of dual leucine zipper kinase and leucine zipper kinase promotes neuronal survival in a model of diffuse traumatic brain injury. Welsbie DS et al., 2019 Nov 27, Mol Neurodegener
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  • Structural plasticity of actin-spectrin membrane skeleton and functional role of actin and spectrin in axon degeneration. Wang G et al., 2019 May 1, Elife
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  • The Ste20 Family Kinases MAP4K4, MINK1, and TNIK Converge to Regulate Stress-Induced JNK Signaling in Neurons. Larhammar M et al., 2017 Nov 15, J Neurosci
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  • Akt suppresses DLK for maintaining self-renewal of mouse embryonic stem cells. Wu CC et al., 2015, Cell Cycle
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