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ProductsBack/dMCL1-2 [2351218-88-5]
CgoaEWY7R2KENqJgAAAAAAMWMJc411.png
CgoaEWY7R2KENqJgAAAAAAMWMJc411.png
CgoaEWY7R2KENqJgAAAAAAMWMJc411.png

dMCL1-2 [2351218-88-5]

Research Use Only
T13657
TargetMol Chemicals
CAS Number2351218-88-5
DownloadMSDS
Product group Chemicals
Molecular Weight1163.3
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    dMCL1-2 [2351218-88-5]
  • Delivery Days Customer
    16
  • CAS Number
    2351218-88-5
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    dMCL1-2
  • Molecular Formula
    C61H66N10O12S
  • Molecular Weight
    1163.3
  • Scientific Description
    dMCL1-2 is a potent and selective myeloid leukemia 1 (MCL1) degrading agent based on PROTAC, binding to MCL1 with a KD of 30 nM and activating the apoptosis mechanism by degrading MCL1.
  • Shelf life instruction
    3 years
  • SMILES
    O=C(O)C1=C(C=2C=CC=C(C=3C(=NN(C3COC4=CC=C(C=C4)N5CCN(CC5)S(=O)(=O)N(C)C)C)C)C2N1CCN6CCN(C(=O)COC7=CC=CC=8C(=O)N(C(=O)C78)C9C(=O)NC(=O)CC9)CC6)CCCOC%10=CC=CC=%11C=CC=CC%10%11
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Papatzimas JW, et al. From Inhibition to Degradation: Targeting the Antiapoptotic Protein Myeloid Cell Leukemia 1 (MCL1). J Med Chem. 2019 Jun 13;62(11):5522-5540.
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