DMTF1 Polyclonal Antibody

Reddot Biotech

DMTF1 Polyclonal Antibody

5

Western Blot

Research Use Only

1 mg/ml

Unconjugated

DMTF1

cyclin D binding myb like transcription factor 1

cyclin D-binding Myb-like protein; cyclin-D-binding Myb-like transcription factor 1; cyclin-D-interacting Myb-like protein 1; DMP1; DMTF; hDMP1; hDMTF1; MRUL

Rabbit

IgG

This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Human

-20°C

12352203