More than 130 suppliers
ISO certified
In-house tech support
we Connect you
Bio-Connect
ProductsBack/DMXAA [117570-53-3]

DMXAA [117570-53-3]

Research Use Only
D509921
LKT Laboratories
Estimated Purity≥98%
Product group Chemicals
€ 338,00
25 mg
Sign in to order and to see your custom pricing.
Large volume orders?
Order with a bulk request
More than 130 suppliers
ISO certified
In-house tech support

Overview

  • Supplier
    LKT Laboratories
  • Product Name
    DMXAA [117570-53-3]
  • Delivery Days Customer
    7
  • Certification
    Research Use Only
  • Estimated Purity
    ≥98%
  • Scientific Description
    Mouse selective STING agonist.; Vadimezan; ASA-404; ASA404; 5,6-Mexaa; NSC 640488
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Weiss JM, Guérin MV, Regnier F.et al, The STING agonist DMXAA triggers a cooperation between T lymphocytes and myeloid cells that leads to tumor regression. Oncoimmunology. 2017 6(10):e1346765. doi10.1080/2162402X.2017. PMID: 29123960. Che X, Du XX, Cai X. et.al., Single Mutations Reshape the Structural Correlation Network of the DMXAA-Human STING Complex. J Phys Chem B. 2017 121(9):2073-2082. PMID: 28178416. Downey CM, Aghaei M, Schwendener RA. et.al., DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2'3'-cGAMP, induces M2 macrophage repolarization. PLoS One. 2014 9(6):e99988. PMID: 24940883. Cerón S, North BJ, Taylor SA, Leib DA. The STING agonist 5,6-dimethylxanthenone-4-acetic acid (DMXAA) stimulates an antiviral state and protects mice against herpes simplex virus-induced neurological disease. Virology. 2019 529:23-28 PMID: 30648635. Kim S, Li L, et al. Anticancer Flavonoids Are Mouse-Selective STING Agonists. ACS Chem. Biol. 2013 8 (7):1396-1401. DOI: 10.1021/cb400264n PMID: 23683494.