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Human Betacellulin, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 92%.

BEN-H525X | Human Betacellulin Protein, Fc Tag | ACRObiosystems available at Bio-Connect

Human Betacellulin Protein, Fc Tag | BEN-H525X | ACRObiosystems

Human Betacellulin Protein, Fc Tag

Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 35.8 kDa. The protein migrates as 45-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. Description: Probetacellulin can be cleaved into the Betacellulin (BTC) that is a single-pass type I membrane protein containing 1 EGF-like domain. Predominantly expressed in pancreas and small intestine,Betacellulin (BTC) is synthesized primarily as a transmembrane precursor, which is then processed to mature molecule by proteolytic events. As a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells, Betacellulin (BTC) is also the growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Betacellulin (BTC) was originally identified as a growth-promoting factor in mouse pancreatic β-cell carcinoma cell line and has since been identified in humans. The amino acid sequence of mature mBTC is 82.5%, identical with that of human BTC (hBTC), and both exhibit significant overall similarity with other members of the EGF family.

Human CD99, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

Human CD99 / MIC2 Protein, Fc Tag (MALS verified) | CD9-H5257 | ACRObiosystems available at Bio-Connect

Human CD99 / MIC2 Protein, Fc Tag (MAL... | CD9-H5257 | ACRObiosystems

Human CD99 / MIC2 Protein, Fc Tag (MALS verified)

Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 36.2 kDa. The protein migrates as 45-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. Description: CD99 antigen is also known as MIC2, single-chain type-1 glycoprotein, HBA71, MIC2X, MIC2Y, MSK5X, 12E7, which belongs to the CD99 family. CD99 / MIC2 is expressed on all leukocytes but highest on thymocytes. Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. CD99 / MIC2 plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. CD99 acts at the same site as, but independently of PECAM1. There is also experimental evidence that it binds to cyclophilin A.

Human LDL R, Fc Tag on SDS-PAGE under reducing (R) and under non-reducing (NR) conditions. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

Immobilized Human PCSK9 (D374Y), His Tag (Cat. No. PCY-H5225) at 5 μg/mL (100 μL/well) can bind Human LDL R, Fc Tag (Cat. No. LDR-H5254) with a linear range of 0.008-0.32 μg/mL (QC tested).

LDR-H5254 | Human LDL R Protein, Fc Tag | ACRObiosystems available at Bio-Connect

Human LDL R Protein, Fc Tag | LDR-H5254 | ACRObiosystems

Human LDL R Protein, Fc Tag

Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 111.4 kDa. As a result of glycosylation, the protein migrates as 155-175 kDa under reducing (R) condition, and 310-350 kDa under non-reducing (NR) condition (SDS-PAGE). Description: Low-Density Lipoprotein (LDL) Receptor is also known as LDLR, FH, FHC, LDLCQ2, and is a mosaic protein of ~840 amino acids (after removal of signal peptide) that mediates the endocytosis of cholesterol-rich LDL. It is a cell-surface receptor that recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles. The receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants (IDL). It belongs to the Low density lipoprotein receptor gene family. LDL receptor complexes are present in clathrin-coated pits (or buds) on the cell surface, which when bound to LDL-cholesterol via adaptin, are pinched off to form clathrin-coated vesicles inside the cell. This allows LDL-cholesterol to be bound and internalized in a process known as endocytosis and prevents the LDL just diffusing around the membrane surface. This occurs in all nucleated cells (not erythrocytes), but mainly in the liver which removes ~70% of LDL from the circulation. Synthesis of receptors in the cell is regulated by the level of free intracellular cholesterol; if it is in excess for the needs of the cell then the transcription of the receptor gene will be inhibited. LDL receptors are translated by ribosomes on the endoplasmic reticulum and are modified by the Golgi apparatus before travelling in vesicles to the cell surface. LDL is directly involved in the development of atherosclerosis, due to accumulation of LDL-cholesterol in the blood. Atherosclerosis is the process responsible for the majority of cardiovascular diseases.

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DNA ladders and protein markers

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