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DNA Ligase 1(1A9), CF405S conjugate, 0.1mg/mL [26628-22-8]

DNA Ligase 1(1A9), CF405S conjugate, 0.1mg/mL [26628-22-8]

BNC042177
Biotium
ApplicationsFunctional Assay, Flow Cytometry, ImmunoPrecipitation
Product group Antibodies
ReactivityBovine, Human, Mouse, Rat
TargetDNAH9
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Overview

  • Supplier
    Biotium
  • Product Name
    DNA Ligase 1(1A9), CF405S conjugate, 0.1mg/mL
  • Delivery Days Customer
    9
  • Applications
    Functional Assay, Flow Cytometry, ImmunoPrecipitation
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    1A9
  • Concentration
    0.1 mg/ml
  • Conjugate
    Other Conjugate
  • Gene ID1770
  • Target name
    DNAH9
  • Target description
    dynein axonemal heavy chain 9
  • Target synonyms
    axonemal beta dynein heavy chain 9; CILD40; ciliary dynein heavy chain 9; DNAH17L; DNAH9 variant protein; Dnahc9; DNEL1; DYH9; dynein axonemal heavy chain 9; dynein heavy chain 9, axonemal; dynein, axonemal, heavy polypeptide 9; HL20; HL-20
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP18858
  • Protein Name
    DNA ligase 1
  • Scientific Description
    DNA Ligase I maintains the major DNA Ligase activity in proliferating cells by joining Okazaki fragments during lagging strand DNA replication. Human DNA Ligase I also has an essential role in DNA repair pathways, where it catalyzes the formation of phosphodiester bonds between adjacent 5 phosphoryl and 3 hydroxy termini at single breaks in duplex DNA molecules. In addition, DNA Ligase I plays a role in sealing nicks during excision repair. Similar to other DNA ligases, DNA Ligase I is built around a common catalytic core. Increased levels of DNA Ligase I are found in human tumors, as compared to benign tissues, as well as in peripheral blood lymphocytes. DNA Ligase I activity is altered in the chromosomal breakage deficit Blooms syndrome (BS). Individuals with BS either have decreased levels of abnormally thermolabile DNA Ligase I or possess a dimeric form of this enzyme. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
  • Source
    Animal
  • Reactivity
    Bovine, Human, Mouse, Rat
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203