DNA Ligase 1(1A9), CF640R conjugate, 0.1mg/mL [26628-22-8]

Biotium

DNA Ligase 1(1A9), CF640R conjugate, 0.1mg/mL

9

Functional Assay, Flow Cytometry, ImmunoPrecipitation

Research Use Only

Monoclonal

1A9

0.1 mg/ml

Other Conjugate

DNAH9

dynein axonemal heavy chain 9

axonemal beta dynein heavy chain 9; CILD40; ciliary dynein heavy chain 9; DNAH17L; DNAH9 variant protein; Dnahc9; DNEL1; DYH9; dynein axonemal heavy chain 9; dynein heavy chain 9, axonemal; dynein, axonemal, heavy polypeptide 9; HL20; HL-20

Mouse

IgG1

DNA ligase 1

DNA Ligase I maintains the major DNA Ligase activity in proliferating cells by joining Okazaki fragments during lagging strand DNA replication. Human DNA Ligase I also has an essential role in DNA repair pathways, where it catalyzes the formation of phosphodiester bonds between adjacent 5 phosphoryl and 3 hydroxy termini at single breaks in duplex DNA molecules. In addition, DNA Ligase I plays a role in sealing nicks during excision repair. Similar to other DNA ligases, DNA Ligase I is built around a common catalytic core. Increased levels of DNA Ligase I are found in human tumors, as compared to benign tissues, as well as in peripheral blood lymphocytes. DNA Ligase I activity is altered in the chromosomal breakage deficit Blooms syndrome (BS). Individuals with BS either have decreased levels of abnormally thermolabile DNA Ligase I or possess a dimeric form of this enzyme. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Animal

Bovine, Human, Mouse, Rat

2°C to 8°C

12352203