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IHC-P analysis of human colon carcinoma tissue using GTX55592 DNA ligase IV antibody. Antigen retrieval : High pressure antigen retrieval with 10 mM citrate buffer pH 6.0 Dilution : 1:100
IHC-P analysis of human colon carcinoma tissue using GTX55592 DNA ligase IV antibody. Antigen retrieval : High pressure antigen retrieval with 10 mM citrate buffer pH 6.0 Dilution : 1:100
IHC-P analysis of human colon carcinoma tissue using GTX55592 DNA ligase IV antibody. Antigen retrieval : High pressure antigen retrieval with 10 mM citrate buffer pH 6.0 Dilution : 1:100

DNA ligase IV antibody

Research Use Only
GTX55592
GeneTex
ApplicationsWestern Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman
TargetLIG4
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Overview

  • Supplier
    GeneTex
  • Product Name
    DNA ligase IV antibody
  • Delivery Days Customer
    9
  • Applications
    Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID3981
  • Target name
    LIG4
  • Target description
    DNA ligase 4
  • Target synonyms
    DNA joinase; DNA ligase 4; DNA ligase IV; DNA repair enzyme; LIG4S; ligase IV, DNA, ATP-dependent; polydeoxyribonucleotide synthase [ATP] 4; polynucleotide ligase; sealase
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
  • Reactivity
    Human
  • Storage Instruction
    2°C to 8°C,-20°C or -80°C
  • UNSPSC
    12352203

References

  • Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance. Schep R et al., 2021 May 20, Mol Cell
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  • Comprehensive Mapping of Histone Modifications at DNA Double-Strand Breaks Deciphers Repair Pathway Chromatin Signatures. Clouaire T et al., 2018 Oct 18, Mol Cell
    Read more