DNAJC10 Antibody, Biotin conjugated

Cusabio

DNAJC10 Antibody, Biotin conjugated

20

ELISA

Research Use Only

Polyclonal

Biotin

DNAJC10

DnaJ heat shock protein family (Hsp40) member C10

DnaJ (Hsp40) homolog, subfamily C, member 10; dnaJ homolog subfamily C member 10; endoplasmic reticulum DNA J domain-containing protein 5; ERdj5; ER-resident protein ERdj5; J-domain-containing protein disulfide isomerase-like protein; JPDI; macrothioredoxin; MTHr; PDIA19; protein disulfide isomerase family A, member 19

Rabbit

IgG

DnaJ homolog subfamily C member 10

Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress.

Human

-20°C or -80°C

12352203