IHC image of CSB-PA809006LA01HU diluted at 1:100 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
DNAJC10 Antibody
CSB-PA809006LA01HU
ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetDNAJC10
Overview
- SupplierCusabio
- Product NameDNAJC10 Antibody
- Delivery Days Customer20
- ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID54431
- Target nameDNAJC10
- Target descriptionDnaJ heat shock protein family (Hsp40) member C10
- Target synonymsDnaJ (Hsp40) homolog, subfamily C, member 10; dnaJ homolog subfamily C member 10; endoplasmic reticulum DNA J domain-containing protein 5; ERdj5; ER-resident protein ERdj5; J-domain-containing protein disulfide isomerase-like protein; JPDI; macrothioredoxin; MTHr; PDIA19; protein disulfide isomerase family A, member 19
- HostRabbit
- IsotypeIgG
- Protein IDQ8IXB1
- Protein NameDnaJ homolog subfamily C member 10
- Scientific DescriptionEndoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203