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DNMT3A antibody

Research Use Only
GTX129125
GeneTex
ApplicationsElectron Microscopy, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetDNMT3A
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Overview

  • Supplier
    GeneTex
  • Product Name
    DNMT3A antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Electron Microscopy, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.28 mg/ml
  • Conjugate
    Unconjugated
  • Formulation
    Liquid
  • Gene ID1788
  • Target name
    DNMT3A
  • Target description
    DNA methyltransferase 3 alpha
  • Target synonyms
    cysteine methyltransferase DNMT3A; DNA (cytosine-5-)-methyltransferase 3 alpha; DNA (cytosine-5)-methyltransferase 3A; DNA cytosine methyltransferase 3A2; DNA MTase HsaIIIA; DNMT3A2; HESJAS; M.HsaIIIA; TBRS
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ9Y6K1
  • Protein Name
    DNA (cytosine-5)-methyltransferase 3A
  • Scientific Description
    CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Epigenetic underpinnings of freeze avoidance in the goldenrod gall moth, Epiblema scudderiana. Williamson SM et al., 2021 Oct, J Insect Physiol
    Read more
  • Insulin and Metformin Control Cell Proliferation by Regulating TDG-Mediated DNA Demethylation in Liver and Breast Cancer Cells. Yan JB et al., 2020 Sep 25, Mol Ther Oncolytics
    Read more
  • Epigenetic Modification and Differentiation Induction of Malignant Glioma Cells by Oligo-Fucoidan. Liao CH et al., 2019 Sep 8, Mar Drugs
    Read more
  • A Tangeretin Derivative Inhibits the Growth of Human Prostate Cancer LNCaP Cells by Epigenetically Restoring p21 Gene Expression and Inhibiting Cancer Stem-like Cell Proliferation. Wei GJ et al., 2019 Jul 10, AAPS J
    Read more
  • Epigenetic targeting DNMT1 of pancreatic ductal adenocarcinoma using interstitial control release biodegrading polymer reduced tumor growth through hedgehog pathway inhibition. Huang MH et al., 2019 Jan, Pharmacol Res
    Read more
  • ETV7-Mediated DNAJC15 Repression Leads to Doxorubicin Resistance in Breast Cancer Cells. Alessandrini F et al., 2018 Aug, Neoplasia
    Read more
  • The inhibitory activity of gallic acid against DNA methylation: application of gallic acid on epigenetic therapy of human cancers. Weng YP et al., 2018 Jan 2, Oncotarget
    Read more
  • Rhein reversal of DNA hypermethylation-associated Klotho suppression ameliorates renal fibrosis in mice. Zhang Q et al., 2016 Oct 5, Sci Rep
    Read more
  • Elevation of soluble guanylate cyclase suppresses proliferation and survival of human breast cancer cells. Wen HC et al., 2015, PLoS One
    Read more