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GTX129125 WB Image
GTX129125 WB Image
GTX129125 WB Image

DNMT3A antibody

Research Use Only
GTX129125
GeneTex
Product group Antibodies
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    GeneTex
  • Product Name
    DNMT3A antibody
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    1.26 mg/ml
  • Isotype
    IgG
  • Scientific Description
    CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • A Tangeretin Derivative Inhibits the Growth of Human Prostate Cancer LNCaP Cells by Epigenetically Restoring p21 Gene Expression and Inhibiting Cancer Stem-like Cell Proliferation. Wei GJ et al., 2019 Jul 10, AAPS J
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  • Elevation of soluble guanylate cyclase suppresses proliferation and survival of human breast cancer cells. Wen HC et al., 2015, PLoS One
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  • Epigenetic Modification and Differentiation Induction of Malignant Glioma Cells by Oligo-Fucoidan. Liao CH et al., 2019 Sep 8, Mar Drugs
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  • Epigenetic targeting DNMT1 of pancreatic ductal adenocarcinoma using interstitial control release biodegrading polymer reduced tumor growth through hedgehog pathway inhibition. Huang MH et al., 2019 Jan, Pharmacol Res
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  • Epigenetic underpinnings of freeze avoidance in the goldenrod gall moth, Epiblema scudderiana. Williamson SM et al., 2021 Oct, J Insect Physiol
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  • ETV7-Mediated DNAJC15 Repression Leads to Doxorubicin Resistance in Breast Cancer Cells. Alessandrini F et al., 2018 Aug, Neoplasia
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  • Insulin and Metformin Control Cell Proliferation by Regulating TDG-Mediated DNA Demethylation in Liver and Breast Cancer Cells. Yan JB et al., 2020 Sep 25, Mol Ther Oncolytics
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  • Rhein reversal of DNA hypermethylation-associated Klotho suppression ameliorates renal fibrosis in mice. Zhang Q et al., 2016 Oct 5, Sci Rep
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  • The inhibitory activity of gallic acid against DNA methylation: application of gallic acid on epigenetic therapy of human cancers. Weng YP et al., 2018 Jan 2, Oncotarget
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