DNMT3A antibody
GTX129125
ApplicationsElectron Microscopy, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetDNMT3A
Overview
- SupplierGeneTex
- Product NameDNMT3A antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsElectron Microscopy, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1.28 mg/ml
- ConjugateUnconjugated
- Gene ID1788
- Target nameDNMT3A
- Target descriptionDNA methyltransferase 3 alpha
- Target synonymsDNMT3A2, HESJAS, M.HsaIIIA, TBRS, DNA (cytosine-5)-methyltransferase 3A, DNA (cytosine-5-)-methyltransferase 3 alpha, DNA MTase HsaIIIA, DNA cytosine methyltransferase 3A2, cysteine methyltransferase DNMT3A
- HostRabbit
- IsotypeIgG
- Protein IDQ9Y6K1
- Protein NameDNA (cytosine-5)-methyltransferase 3A
- Scientific DescriptionCpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Casali C, Galgano L, Zannino L, et al. Impact of heat and cold shock on epigenetics and chromatin structure. Eur J Cell Biol. 2024,103(1):151373. doi: 10.1016/j.ejcb.2023.151373Read this paper
- Wu YH, Huang YF, Wu PY, et al. The downregulation of miR-509-3p expression by collagen type XI alpha 1-regulated hypermethylation facilitates cancer progression and chemoresistance via the DNA methyltransferase 1/Small ubiquitin-like modifier-3 axis in ovarian cancer cells. J Ovarian Res. 2023,16(1):124. doi: 10.1186/s13048-023-01191-5Read this paper
- Wu YH, Huang YF, Wu PY, et al. The Downregulation of miR-509-3p Expression by Collagen Type XI Alpha 1-Regulated Hypermethylation Facilitates Cancer Progression and Chemoresistance via the DNA Methyltransferase 1/Small Ubiquitin-like Modifier-3 Axis in Ovarian Cancer Cells. Res Sq. 2023,:pii: rs.3.rs-2592453. doi: 10.21203/rs.3.rs-2592453/v1.Read this paper
- Williamson SM, Ingelson-Filpula WA, Hadj-Moussa H, et al. Epigenetic underpinnings of freeze avoidance in the goldenrod gall moth, Epiblema scudderiana. J Insect Physiol. 2021,134:104298. doi: 10.1016/j.jinsphys.2021.104298Read this paper
- Yan JB, Lai CC, Jhu JW, et al. Insulin and Metformin Control Cell Proliferation by Regulating TDG-Mediated DNA Demethylation in Liver and Breast Cancer Cells. Mol Ther Oncolytics. 2020,18:282-294. doi: 10.1016/j.omto.2020.06.010Read this paper
- Liao CH, Lai IC, Kuo HC, et al. Epigenetic Modification and Differentiation Induction of Malignant Glioma Cells by Oligo-Fucoidan. Mar Drugs. 2019,17(9). doi: 10.3390/md17090525Read this paper
- Wei GJ, Chao YH, Tung YC, et al. A Tangeretin Derivative Inhibits the Growth of Human Prostate Cancer LNCaP Cells by Epigenetically Restoring p21 Gene Expression and Inhibiting Cancer Stem-like Cell Proliferation. AAPS J. 2019,21(5):86. doi: 10.1208/s12248-019-0345-7Read this paper
- Huang MH, Chou YW, Li MH, et al. Epigenetic targeting DNMT1 of pancreatic ductal adenocarcinoma using interstitial control release biodegrading polymer reduced tumor growth through hedgehog pathway inhibition. Pharmacol Res. 2019,139:50-61. doi: 10.1016/j.phrs.2018.10.015Read this paper
- Alessandrini F, Pezzè L, Menendez D, et al. ETV7-Mediated DNAJC15 Repression Leads to Doxorubicin Resistance in Breast Cancer Cells. Neoplasia. 2018,20(8):857-870. doi: 10.1016/j.neo.2018.06.008Read this paper
- Weng YP, Hung PF, Ku WY, et al. The inhibitory activity of gallic acid against DNA methylation: application of gallic acid on epigenetic therapy of human cancers. Oncotarget. 2018,9(1):361-374. doi: 10.18632/oncotarget.23015Read this paper
Datasheet
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