DNMT3B antibody

GeneTex

DNMT3B antibody

9

WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

Dnmt3b

DNA methyltransferase 3B

DNA (cytosine-5)-methyltransferase 3B; DNA methyltransferase MmuIIIB; DNA MTase MmuIIIB; MmuIIIB

Rabbit

IgG

DNA (cytosine-5)-methyltransferase 3B

Required for genome wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.

Mouse

-20°C or -80°C,2°C to 8°C

12352203