DNMT3B Polyclonal Antibody

Reddot Biotech

DNMT3B Polyclonal Antibody

5

ImmunoFluorescence, Western Blot

Research Use Only

1 mg/ml

Unconjugated

DNMT3B

DNA methyltransferase 3 beta

DNA (cytosine-5-)-methyltransferase 3 beta; DNA (cytosine-5)-methyltransferase 3B; DNA cytosine-5--methyltransferase 3 beta; DNA methyltransferase HsaIIIB; DNA MTase HsaIIIB; FSHD4; ICF; ICF1; M.HsaIIIB

Rabbit

IgG

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.

Human, Mouse, Rat

-20°C

12352203