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DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/1487R), CF640R conjugate, 0.1mg/mL [26628-22-8]

BNC401487
Biotium
ReactivityBovine, Human, Rabbit
Product group Antibodies
TargetANO1
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Overview

  • Supplier
    Biotium
  • Product Name
    DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/1487R), CF640R conjugate, 0.1mg/mL
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    DG1/1487R
  • Concentration
    0.1 mg/ml
  • Conjugate
    Other Conjugate
  • Gene ID55107
  • Target name
    ANO1
  • Target description
    anoctamin 1
  • Target synonyms
    anoctamin 1, calcium activated chloride channel; anoctamin-1; Ca2+-activated Cl- channel; calcium activated chloride channel; discovered on gastrointestinal stromal tumors protein 1; DOG1; oral cancer overexpressed 2; ORAOV2; TAOS2; TMEM16A; transmembrane protein 16A (eight membrane-spanning domains); tumor-amplified and overexpressed sequence 2
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ5XXA6
  • Protein Name
    Anoctamin-1
  • Scientific Description
    Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GIST s), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GIST s, including all c-kit negative GIST s. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GIST s is nearly identical: 94.4% vs. 94.7%.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
  • Source
    Animal
  • Reactivity
    Bovine, Human, Rabbit
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203