Bio-Connect

Donepezil Hydrochloride [120011-70-3]

Research Use Only
D5753
LKT Laboratories
Estimated Purity≥98%
Product group Chemicals
€ 330,00
100 mg
Sign in to order and to see your custom pricing.
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    LKT Laboratories
  • Product Name
    Donepezil Hydrochloride [120011-70-3]
  • Delivery Days Customer
    7
  • Certification
    Research Use Only
  • Estimated Purity
    ≥98%
  • Scientific Description
    GSK3 and AChE inhibitor, potential σ1 agonist.; Aricept, BNAG
  • Storage Instruction
    Ambient
  • UNSPSC
    12352200

References

  • Jiang Y, Zou Y, Chen S, et al. The anti-inflammatory effect of donepezil on experimental autoimmune encephalomyelitis in C57 BL/6 mice. Neuropharmacology. 2013 Oct;73:415-24. PMID: 23831366. Xia Z, Zhang R, Wu P, et al. Memory defect induced by bèta-amyloid plus glutamate receptor agonist is alleviated by catalpol and donepezil through different mechanisms. Brain Res. 2012 Mar 2;1441:27-37. PMID: 22305339. Shen H, Kihara T, Hongo H, et al. Neuroprotection by donepezil against glutamate excitotoxicity involves stimulation of alpha7 nicotinic receptors and internalization of NMDA receptors. Br J Pharmacol. 2010 Sep;161(1):127-39. Erratum in: Br J Pharmacol. 2010 Nov;161(5):1200. PMID: 20718745. Handa T, Katare RG, Kakinuma Y, et al. Anti-Alzheimer's drug, donepezil, markedly improves long-term survival after chronic heart failure in mice. J Card Fail. 2009 Nov;15(9):805-11. PMID: 19879468. Ishikawa M, Sakata M, Ishii K, et al. High occupancy of sigma1 receptors in the human brain after single oral administration of donepezil: a positron emission tomography study using [11C]SA4503. Int J Neuropsychopharmacol. 2009 Sep;12(8):1127-31. PMID: 19573265. Noh MY, Koh SH, Kim Y, et al. Neuroprotective effects of donepezil through inhibition of GSK-3 activity in amyloid-beta-induced neuronal cell death. J Neurochem. 2009 Mar;108(5):1116-25. PMID: 19077054.