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DOTA-bis(tert-butyl)ester

HY-W241345
MedChem Express
Molecular Weight516.63
Product group Chemicals
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Overview

  • Supplier
    MedChem Express
  • Product Name
    DOTA-bis(tert-butyl)ester
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Molecular Formula
    C24H44N4O8
  • Molecular Weight
    516.63
  • Scientific Description
    DOTA-bis(tert-butyl)ester is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide conjugates (RDCs). DOTA-bis(tert-butyl)ester can be conjugated with different salts to form different metal chelators, such as (HY-B1244) hydrochloride to obtain DOTA-MN2. DOTA-MN2 can be reacted with [67]Ga-citrate to obtain radiolabeling. When (67)Ga-DOTA-MN2 is incubated in phosphate buffer solution or mouse plasma for 24 hours, it does not undergo significant decomposition. In the biodistribution experiment of NFSa tumor mice, it has high tumor uptake and rapid plasma clearance, and is a good material for SPECT and PET studies.
  • SMILES
    O=C(OC(C)(C)C)CN1CCN(CC(O)=O)CCN(CC(OC(C)(C)C)=O)CCN(CC(O)=O)CC1
  • UNSPSC
    12352200