DOTAGA-anhydride
HY-W087187
Estimated Purity99.80
Product group Chemicals
Molecular Weight458.46
Overview
- SupplierMedChem Express
- Product NameDOTAGA-anhydride
- Delivery Days Customer9
- CertificationResearch Use Only
- Estimated Purity99.80
- Molecular FormulaC19H30N4O9
- Molecular Weight458.46
- Scientific DescriptionDOTAGA-anhydride is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide drug conjugates (RDCs). DOTAGA-anhydride can be used to label monoclonal antibodies (mAbs) such as trastuzumab (targeting HER2/neu receptor with an affinity of 5.5 nM) under mild conditions (PBS pH 7.4, 25 °C, 30 minutes) after chelation with indium-111. [111In-DOTAGA]-trastuzumab showed a tumor uptake of 65% ID/g in mice bearing breast cancer BT-474 xenografts 72 hours after injection, which is valuable for SPECT/CT imaging and biodistribution studies.
- SMILESO=C(O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(C(CCC(O2)=O)C2=O)CC1
- Storage Instruction-80°C
- UNSPSC12352200