Bio-Connect

DOTAGA-anhydride

HY-W087187
MedChem Express
Estimated Purity99.80
Product group Chemicals
Molecular Weight458.46
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Overview

  • Supplier
    MedChem Express
  • Product Name
    DOTAGA-anhydride
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Estimated Purity
    99.80
  • Molecular Formula
    C19H30N4O9
  • Molecular Weight
    458.46
  • Scientific Description
    DOTAGA-anhydride is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide drug conjugates (RDCs). DOTAGA-anhydride can be used to label monoclonal antibodies (mAbs) such as trastuzumab (targeting HER2/neu receptor with an affinity of 5.5 nM) under mild conditions (PBS pH 7.4, 25 °C, 30 minutes) after chelation with indium-111. [111In-DOTAGA]-trastuzumab showed a tumor uptake of 65% ID/g in mice bearing breast cancer BT-474 xenografts 72 hours after injection, which is valuable for SPECT/CT imaging and biodistribution studies.
  • SMILES
    O=C(O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(C(CCC(O2)=O)C2=O)CC1
  • Storage Instruction
    -80°C
  • UNSPSC
    12352200