DOV-216,303 (Free Base)

MedChem Express

DOV-216,303 (Free Base) [66504-40-3]

5

66504-40-3

Research Use Only

98.77

C11H11Cl2N

228.12

DOV-216,303 (Free Base) is a potent triple serotonin, norepinephrine, and dopamine reuptake inhibitor, with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively[1]. Has antidepressant-like effects and increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats[2].

ClC1=C(Cl)C=C(C=C1)C12CC1CNC2

-20°C,2°C to 8°C

12352200