DR1 Polyclonal Antibody

Reddot Biotech

DR1 Polyclonal Antibody

5

ImmunoFluorescence, ImmunoHistoChemistry

Research Use Only

1 mg/ml

Unconjugated

DR1

down-regulator of transcription 1

NC2; NC2B; NC2-BETA; NCB2; negative cofactor 2; negative cofactor 2-beta; protein Dr1; TATA-binding protein-associated phosphoprotein

Rabbit

IgG

This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.

Human, Mouse

-20°C

12352203